Okay....are you guys ready for this one? I wish I could say I was, but it's too important for us as a field to not think about....
"Analytical figures of merit"?? Hey! This is the proteomics party, don't you come in here with all your boring analytical chemistry validation stuff....oh.....ugh...okay....
(Yes. I had to make that. You're welcome.)
Why is this (study) important? In part because it addresses 2 separate concepts that need to be separated -- and they're right in the abstract:
"....Our results demonstrate that increasing the number of detected peptides in a proteomics experiment does not necessarily result in increased numbers of peptides that can be measured quantitatively....."
First of all, this study is like 4 pages or something and it represents an absurd amount of work. SRMs and DIA experiments (QE HF, I think) and a bunch of different HPLCs and the matrices are all sorts of fun -- CSF and FFPE and yeast digest and maybe I mi..