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Talking About ICON

ICON went limit up for the wrong reasons. Some are saying its because the terms were so convoluted and that not many know how to calculate the capital reduction. PLEASE, this is not your first rodeo, this is not the first capital reduction exercise. You are all supposed to be professional investors or advisors. The limit up was obviously caused by the 50 into one capital reduction. A simple calculation showed that ICON had 2.377bn shares. Divide that by 50 = 47.5 million shares. That must be close to the fewest number of shares listed by a company on Bursa. The complaining parties ARE those who SOLD SHORT unwittingly. Imagine you had 100,000 prior to the ex date. It was trading at 4 sen, you value was RM4,000, and as with 99.9999% of ICON investors, you had lost money already big time. Then you woke up and saw the price going limit up. (0.035 x 50) + (100 × 0.105) ÷ 101 = 0.12 Add the 30 sen limit up, you have 42 sen, today add another 30 sen you have 72 sen. As you can see even at 72..

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BioPlex Update Preprint — 5,500 New Protein Interactomes — in a new cell line!

Ummm....so on a scale of 1 to BioPlex -- how big is your big proteomics data? Holy cow. You know, sometimes when you don't hear about these huge proteomics undertakings its easy to think "maybe they thought the first 10,000 human proteome interactomes was enough..." NOPE. BioPlex is alive and well and providing human protein protein interaction data at a pace that doesn't quite seem possible. Proof? Check out this new preprint! Not familiar with BioPlex? It is a bulldozer type approach to human protein interactions. Instead of doing something complicated and elegant -- why not just synthesize every open reading frame in humans and do an expert level immunoprecipitation -- mass spectrometry experiment on them. Yeah -- every one! BioPlex 3.0 showed about half the theoretical human proteome. For real. It is a project so big and ambitious that is is easy to forget about. How do you take this another step forward? Well -- you throw in some different cell types. And instead of lo..

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أسعار الذهب في مصر اليوم الاربعاء 22/1/2020

سجلت أسعار الذهب في مصر اليوم الاربعاء 22/1/2020، انخفاض في الأسعار لليوم، ليسجل عيار 21 الأكثر تداولا فى الاسواق المصرية 683 جنيها، ونستمر على موقع أخبار البلد اليوم عرض تحديث لأخر المتغيرات السعرية التي تشهدها أسواق الذهب في مصر بالجنيه المصري والدولار الأمريكي، لكافة قراء ومتابعي أخبار البلد اليوم، اليوم الاربعاء 22 يناير 2020 . وتتأثر أسعار الذهب في مصر بعدة عوامل منها حالة العرض والطلب بالإضافة إلى أسعار الذهب عالميا وأسعار الدولار، ونواصل الآن عرض متوسط أسعار الذهب اليوم الاربعاء 22/1/2020، بالجنية المصري والدولار الأمريكي، ونعرض الآن تقارير تفصيلية شاملة لكافة أسعار الذهب اليوم في جمهورية مصر العربية، بالكيلو والأوقية وجنية الذهب. تحديث أسعار الذهب في مصر الاربعاء 22/1/2020و قد سجلت أسعار الذهب في مصر اليوم الاربعاء 22 يناير 2020 انخفاض في الأسعار لليوم بمعدل جنية، لتسجل أسعار الذهب بدون مصنعية اليوم :- سعر جرام الذهب عيار 24 :اليوم بدون مصنعية نحو 781 جنيها. سعر جرام الذهب عيار 21 : اليوم بدون مصنعية عند 683 جنيهاً.سعر جرام الذهب عيار 18 :اليوم بدون مصنعية نحو 585 جنيها. ونعرض..

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CyTOF data on single cells for 281 cancer patients with long term clinical data!

Somewhere around you, possibly within walking distance, depending on the relative funding level and decision making skills of your administrators is probably a big grey and orange box like the thing above. I'd be comfortable betting you $1.14 that it probably isn't doing anything right this second. This box is called a CyTOF and -- I swear -- it has all sorts of promise, but it's a bit of technology that is seeking a real application. And I'm going to jump on every paper I see that suggests we may have finally found it. Imagine that you're doing flow cytometry. You've tagged your cells with a couple of proteins and these proteins have a dye on them. The instrument measures the intensity of these dyes as the cells are sorted and you basically get single cell data on the intensity of these two proteins in each single cell. Now upgrade that idea and replace the dyes with protein tags that you can see with a mass spec. The cells get sorted, go through, get ion..

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Announcing the First Ever News In Proteomics MineAthon (Challenge)!

I have been working on yet another crazy idea off and on for a month or two and it's now almost (like 18%) fully organized. I'll stand by these words all day. Proteomics hardware is about mature. Yeah, we'll get some cooler stuff down the road, but until we figure out how to fix our informatics problem -- who cares if you get 3% more peptide IDs or 10% more spectra? Most of the tools people are using are only converting a tiny percentage of spectra into biological findings. There is much more to be gained with smarter data processing than even applying phase constraint over a wider mass range. In the most popular data processing pipelines people aren't even looking for PTMs, because it's still really hard to do it. SO....Let's see where we are right now! Do you think your data processing pipeline is the best for finding important biological changes and PTMs? Want to prove it, participate in some cool human research, be on a cool paper, a wold-wide webcast ..

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Announcing the First Ever News In Proteomics MineAthon!

I have been working on yet another crazy idea off and on for a month or two and it's now almost (like 18%) fully organized. I'll stand by these words all day. Proteomics hardware is about mature. Yeah, we'll get some cooler stuff down the road, but until we figure out how to fix our informatics problem -- who cares if you get 3% more peptide IDs or 10% more spectra? Most of the tools people are using are only converting a tiny percentage of spectra into biological findings. There is much more to be gained with smarter data processing than even applying phase constraint over a wider mass range. In the most popular data processing pipelines people aren't even looking for PTMs, because it's still really hard to do it. SO....Let's see where we are right now! Do you think your data processing pipeline is the best for finding important biological changes and PTMs? Want to prove it, participate in some cool human research, be on a cool paper, a wold-wide webcast ..

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أسعار الذهب في مصر اليوم الثلاثاء 21/1/2020

سجلت أسعار الذهب في مصر اليوم الثلاثاء 21/1/2020، ثبات في الأسعار لليوم على التوالي، ليسجل عيار 21 الأكثر تداولا فى الاسواق المصرية 684 جنيها، ونستمر على موقع أخبار البلد اليوم عرض تحديث لأخر المتغيرات السعرية التي تشهدها أسواق الذهب في مصر بالجنيه المصري والدولار الأمريكي، لكافة قراء ومتابعي أخبار البلد اليوم، اليوم الثلاثاء 21 يناير 2020 . وتتأثر أسعار الذهب في مصر بعدة عوامل منها حالة العرض والطلب بالإضافة إلى أسعار الذهب عالميا وأسعار الدولار، ونواصل الآن عرض متوسط أسعار الذهب اليوم الثلاثاء 21/1/2020، بالجنية المصري والدولار الأمريكي، ونعرض الآن تقارير تفصيلية شاملة لكافة أسعار الذهب اليوم في جمهورية مصر العربية، بالكيلو والأوقية وجنية الذهب. تحديث أسعار الذهب في مصر الثلاثاء 21/1/2020و قد سجلت أسعار الذهب في مصر اليوم الثلاثاء 21 يناير 2020 استقرار في الأسعار لليوم، لتسجل أسعار الذهب بدون مصنعية اليوم :- سعر جرام الذهب عيار 24 :اليوم بدون مصنعية نحو 782 جنيها. سعر جرام الذهب عيار 21 : اليوم بدون مصنعية عند 684 جنيهاً.سعر جرام الذهب عيار 18 :اليوم بدون مصنعية نحو 586 جنيها. ونعرض..

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ShinyGO! A beautiful, simple and powerful online data interpretation tool.

I didn't want to write about this one until I got these stupid manuscript edits out the door, because I needed ShinyGO and I didn't want anyone else slowing it down. "Minor" edits done! Tool sharing time! You can read about ShinyGO here. Don't feel like reading? You can play with ShinyGO online here! Are there lots of tools like this out there hiding on the web? Yup! There sure are, but this honestly might be the easiest way to dig through a bunch of different resources all at once. You will need to get your protein list to universal gene identifiers or something similar (it'll translate several different types) and then you can start doing all sorts of analyses. For the figure above, I let ShinyGO select the closest related organism (ended up being Scumbag Arabidopsis) and I flipped through different databases until I got some visualizations that made my data make some sense (turned out being a nice visualization of KEGG resources with pathway representation scale..

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أسعار الذهب في مصر اليوم الأحد 19/1/2020

سجلت أسعار الذهب في مصر اليوم الاحد 19/1/2020، ثبات في الأسعار لليوم ، ليسجل عيار 21 الأكثر تداولا فى الاسواق المصرية 684 جنيها، ونستمر على موقع أخبار البلد اليوم عرض تحديث لأخر المتغيرات السعرية التي تشهدها أسواق الذهب في مصر بالجنيه المصري والدولار الأمريكي، لكافة قراء ومتابعي أخبار البلد اليوم، اليوم الأحد 19 يناير 2020 . وتتأثر أسعار الذهب في مصر بعدة عوامل منها حالة العرض والطلب بالإضافة إلى أسعار الذهب عالميا وأسعار الدولار، ونواصل الآن عرض متوسط أسعار الذهب اليوم الأحد 19/1/2020، بالجنية المصري والدولار الأمريكي، ونعرض الآن تقارير تفصيلية شاملة لكافة أسعار الذهب اليوم في جمهورية مصر العربية، بالكيلو والأوقية وجنية الذهب. تحديث أسعار الذهب في مصر الأحد 19/1/2020و قد سجلت أسعار الذهب في مصر اليوم الأحد 19 يناير 2020 استقرار في الأسعار لليوم، لتسجل أسعار الذهب بدون مصنعية اليوم :- سعر جرام الذهب عيار 24 :اليوم بدون مصنعية نحو 782 جنيها. سعر جرام الذهب عيار 21 : اليوم بدون مصنعية عند 684 جنيهاً.سعر جرام الذهب عيار 18 :اليوم بدون مصنعية نحو 586 جنيها. ونعرض الآن متوسط أسعار الذهب لم..

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At long last — A Guidance Document for HLA Peptides!

Twenty somethig years of analyzing HLA Class I/II antigens with mass spectrometry and we need to face facts -- mass spectrometry of these things still sucks. Important? Yes. Super incredibly important. But mobile protons are NOT a fun thing for us to work with as our exclusive charge acceptor. Our technologies work best with doubly charged peptides that end in lysines or arginines. But LCMS is the only thing that has ever worked at all for these molecules, so we're stuck with them. What we need is a set of guidelines to at least reference --- and here is the first one I've seen! Honestly, I expected this to have maybe 50 different authors on it as some sort of an over arching consensus of a big meeting on the topic to sort it out. And, that might make me a little more comfortable, but I tell you what, this document is not bad at all. You know why? This group has actually validated some HLA peptides and successfully utilized them! This isn't a big hypothetical piece. Th..

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